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For instance, to test the effect on resistance to pathogens, one could assess the response to a vaccination or combine the assessment of endpoints with specific responsiveness to an experimental infection.
But we include only patients without acupuncture experience for gonarthrosis and have blinded assessment of endpoints.
The participants of both groups then receive a clinical examination, comprehensive geriatric assessment and assessment of endpoints.
Use of data from central registers further blinded the assessment of endpoints in relation to randomisation group.
Assessment of endpoints becomes more important in later clinical studies, and it is also important to collect, store, and analyze patient samples.
Assessment of endpoints will be achieved using a combination of physician and patient report and record linkage to routinely collected health data.
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Assessment of endpoint variability in a large sample size is necessary and should be considered in the choice of statistical tests, as the type of variability (normal distribution versus skewed) dictates a parametric versus non-parametric statistical analysis of the data.
Likewise, for placebos intended for topical use, the property of pH deserves particular attention; the differences in pH between the two products may lead to local irritation in one group only, and therefore distinct side-effects profile will effectively unblind the treatment arm and biased assessments of endpoints may result.
Regarding evaluated endpoints, while acute toxicity brought limited information, the assessment of specific endpoints was of strong value for bioactivity identification.
The assessment of multiple endpoints simultaneously, and evaluation of the data in the context of the clinical concentration at which structural cardiotoxicity was observed, allows insight into mechanisms of structural cardiotoxins via the development of a unique fingerprint of alterations for each compound.
Alternative approaches, such as modeling cellular changes observed in animal studies, may be more useful for quantitative risk assessment of noncancer endpoints and should be used as an adjunct to interpreting human sensory studies.
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