Your English writing platform
Discover LudwigSuggestions(1)
Exact(2)
Biological samples from cases and controls were analyzed for a wide spectrum of psychoactive substances, thereby allowing for a better assessment of combinations of psychoactive substances.
Thus, further preclinical assessment of combinations of JAK2 inhibitors with Bcl-2 family antagonists in models of cMPNs is warranted and antagonizing Mcl-1, besides Bcl-xL, should be an integral part of such strategies.
Similar(58)
A substantial challenge lies in the assessment of combination effects from large numbers of endocrine disrupters and other chemicals, all at low doses.
In contrast, the assessment of combination effects has a long tradition in pharmacology, where mixtures of chemicals are specifically designed to develop new products, e.g. human and veterinary drugs or agricultural and non-agricultural pesticides.
We consider both reference models as useful tools for the assessment of combination effects of multiple mixtures of xenoestrogens.
Hopefully, this work can provide some insights to tackle the challenging problem of assessment of combination drug therapy effct in a large scale signaling pathways.
While these considerations will be useful when it comes to the evaluation of experimental data, we have doubts whether they will be relevant for the assessment of combination effects of aneugens and clastogens in risk assessment practice.
The possibility of myopathy, especially with statin-fibrate combinations, has prevented health care professionals from more aggressive risk assessment of combination dyslipidemia, such as atherogenic or diabetic dyslipidemia, and initiating combination drug therapy.
Most of the studies of thyroid-disrupting effects have analyzed the effects of mixtures without recording responses induced by individual mixture components; this complicates assessment of combination effects in terms of additivity, synergism, or antagonism.
Thus, approaches are required that provide more reliable calculations of mixture effects, such that a reference point for the assessment of combination effects in terms of synergisms, additivity, and antagonism can be defined.
The wide variety of studies reviewed here provides a comprehensive assessment of combination therapy with GLP-1 RAs and basal insulin to improve glycaemic control and reduce body weight with a low risk of hypoglycaemia.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com