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Therefore, a better assessment marker of the fibrosis activity and comprehensive understanding of the underlying mechanisms of collagen over-production may provide new strategies for the anti-fibrotic treatment of SSc.
Autoimmune conditions like GBS can stimulate the production of a high level of inflammation resulting in an increase in the CRP production, so highly sensitive CRP assay may become a new risk assessment marker in the future for autoimmune disorders including GBS (Vaishnavi et al. 2014).
This study was designed according to the predictive marker trial design 'Indirect assessment: marker by treatment interaction design, test of interaction' (design 2) [ 25].
This study was designed according to the REporting recommendations for tumor MArker prognostic studies (REMARK) guidelines [ 27] following the predictive marker trial design of 'Indirect assessment: Marker by treatment interaction design, test of interaction' as described by Sargent et al. [ 28].
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The mean scale score across the studies was 6 out of 9, with two studies satisfying less than half of the quality assessment markers.
20 For the 15 m COD sprint assessment, markers were set at 0, 5 and 10 m from the extended baseline alongside the tennis court.
Abbreviations as in Tables 1, 2, 3. Finally, we compared the predictive power of FRS for atherosclerotic events against other vascular assessment markers, alone and in combination with the FRS (Table 5).
The assessment of marker transmission ratio distortion found that 26% of the genotyped markers were distorted from either 1 1 or 3 1 ratios expected for segregation of single dose markers in one or both parents, respectively.
"Nonparametric benefit-risk assessment using marker process in the presence of a terminal event". Journal of the American Statistical Association: 112 518).
Quality control for this dataset included assessment of marker genotype frequency, allelic frequency, and departure from Hardy-Weinberg equilibrium.
Quality control for this dataset included sample genotyping efficiency, assessment of marker heterozygosity and allelic frequency, departure from Hardy Weinberg equilibrium, gender consistency, reproducibility and population genetic structure.
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