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The instrument had to be administered by observation of physical performance to counter assessment limitations associated with cognitive deficits and recall bias in hospitalised older patients.
Potency differences for predominantly chrysotile versus amphibole asbestos-exposed cohorts become difficult to ascertain when meta-analyses are restricted to studies with fewer exposure assessment limitations.
However, exposure assessment limitations likely contributed to heterogeneity in study-specific potencies as well, because of attenuation of exposure response relations (KL values) resulting from varying degrees of misclassification of exposure.
The Quebec mine cohort, in contrast, suffers from several exposure assessment limitations, such as incomplete job history information and undocumented moving between mines and mills; the exposure response was relatively flat.
Overall, a small number of sites have been identified by available evidence on the human body as suspected targets, especially the bladder, but drawing crucial conclusions regarding causality is hindered by intrinsic questions such as methodological drawbacks, exposure assessment limitations [ 38, 40].
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The health assessment questionnaire (HAQ) assessed limitation of daily activities with scores ranging from 0 to 3, where the minimal score indicates the best health condition.
Due to the small sample size of this assessment, several limitations need to be considered.
We close on comments regarding implications for exposure and risk assessment, and limitations of the model.
Our historical cancer assessment has limitations that are commonplace with analysing population-level data.
This assessment has limitations that should be kept in mind when interpreting the results.
Additional file 1 provides detailed assessment of limitations for ADLs and pain over time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com