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Clinical assessment in the sample with MPFC lesions was performed by using a non-structured clinical interview and Brief Psychiatric Rating Scale (BPRS) version 4.0 translated into Italian by [ 39] and through the neuropsychiatric Inventory (NPI), a semistructured clinicians interview using the protocol described by [ 40].
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At baseline assessment, subjects in the sample were assessed for psychiatric disorders (Axis I disorders assessed through SCID-I interview [ 9], and SCID-II interviews [ 10], were given a thorough medical examination, completed several personality tests, intelligence tests, and completed psychiatric self-rating scales. When indicated, women also underwent neuropsychological assessment.
The new-onset of Diagnostic and Statistical Manual of Mental Disorder, fourth edition defined depressive disorder in the offspring using established research diagnostic assessments the Child and Adolescent Psychiatric Assessment in the high-risk sample and the Development and Wellbeing Assessment in the replication sample.
A limitation of the study is the lack of psychiatric disorder assessment in the school sample.
The scale was relatively brief and valid as well as adequate for suicide risk assessment in the clinical sample.
The performance of CAT-Health in HRQoL assessment in the studied sample, which covered a broad spectrum of individuals attending primary care settings, indicates a good potential for the evaluation of the general population.
In a previous study [ 33] we tested the validity of personality assessment in the ECA sample and found adequate alpha reliabilities, retest-stability, and factor structure of the NEO-PI-R scales.
For the DEMMI, only 3 patients (2.8%) scored above 90 and 5 patients (4.7%) scored less than 10 at their initial assessment in the validation sample and therefore the DEMMI provided the scale width required to adequately measure clinically important change for all older acute medical patients included in this study.
The results justify the a priori assumption of effect modification due to differences in the quality of noise exposure assessment in the two samples (Greenland 1989; Hennekens and Buring 1987).
The average time to complete each of the first two SCIP assessments in the bipolar sample was 15.61 (SD = 5.01) and 14.16 (SD = 4.92) minutes.
Based on the type of consent that parents have given, we will create three different categories in the sample (assessment including parents only; assessment of parents and children; and assessment of parents and children, including biological testing).
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