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Whether multiple sampling is needed for exposure assessment in specific situations (e.g., during pregnancy) will depend mainly on the intraperson variability at the sampling time (e.g., noon) and throughout the study period (e.g., 1 week).
However, more comprehensive measurement is often tied up with less sensitive assessment in specific domains as shown in various studies: In the assessment of shoulder arthritis, a dose-response curve of specificity and responsiveness could be empirically proven [ 4].
We discuss advantages and drawbacks of standardized competence assessment in children on a case-by-case basis compared to application of a fixed age limit, and conclude that a selective implementation of case-by-case competence assessment in specific populations is preferable.
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(The idea is that this frees up the humans to make more sophisticated assessments in specific cases, or focus on entirely different tasks).
Further risk-benefit assessments in specific clinical contexts would be helpful.
This shift in approach from traditional clinical and histopathological risk assessment, which provides estimates of outcomes from disease and interventions for a similar population of patients, to specific tumour assessment in a specific patient with a genetic basis for prognosis and treatment decisions is exciting.
The aim of this study was to investigate the clinical, histological and molecular factors involved in early local recurrence of OSCC, which may lead to better risk assessment in some specific cases.
In addition, the variability of this association when adjusted for the degree of fever or illness severity or the presence of suspected infection further invite assessment in such specific groups.
Probably, these methods will be available in a near future for cure assessment in genotype-specific approaches.
This suggests that some allowance for this phenomenon is needed for an accurate assessment of change in specific myocardial uptake over time in these subjects.
The Institute for Quality and Efficiency in Health Care (Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen, IQWiG) publishes its own methods on assessments in a specific method paper including key elements on how assessments are to be carried out [1].
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