We measured several GO-based quantities to assess module quality.
We then assessed module synteny between the four strains studied, by aligning conserved modules on linear genomic maps.
We ran separate WGCNA analyses for each sex (n = 7 for females and n = 8 for males) to assess module preservation across sex.
To assess module specificity, we compared the performance of each of them in the disease in which they were identified against its performance across all other diseases.
To compare the performances of unsigned and signed WGCNA in identifying gene groups that are important for the regulation of the pluripotent state, we defined gene modules in unsigned and signed networks and assessed module function and importance by determining gene ontology terms associated with each module and examining module membership of genes known to play a role in ES cells.
Moreover, known protein complexes are largely incorporated in the assessed modules.
First, the project team was responsible for developing the GEM module, recruiting participating practices, assisting with implementation, and assessing the module (e.g., uptake and provider satisfaction with it).
Module significance for either a continuous or dichotomous outcome is determined assessing eigengene module significance.
At intake, 13 children were assessed with Module 1 and five children with Module 2. At follow-up, 11 children were assessed with Module 1 and seven children with Module 2. KSPD, Kyoto Scale Psychological Development Test.
Network module preservation statistics assess whether modules identified in the reference network remain connected in the test network (density), and whether node connections are similar between the reference and the test network (connectivity).
