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We nevertheless acknowledge limitations such as the difficulty in adequately assessing cognitive function in children with ASD.
We used two complementary approaches to assessing cognitive function.
Of course, assessing cognitive function in multi-institutional, often multi-national, studies is potentially challenging.
A common tool for assessing cognitive function is the Mini Mental Status Examination (MMSE) [ 50].
These include taking a careful history from patients and their families, and assessing cognitive function by neuropsychologic tests.
The scale has been validated using psychometric analyses, with the conclusion that the S-MMSE is a reliable instrument and a valuable tool for assessing cognitive function [ 55].
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Based on the review, clinical recommendations include assessing cognitive functioning and personality disorders at baseline and continuous monitoring of treatment alliance.
Methodologically, assessing cognitive functioning via the telephone is a reliable and valid approach [ 28- 31].
The tasks are appealing for young children, which is important when assessing cognitive functions of 3-year olds.
The MMSE [ 19] is the most commonly used instrument to gauge the severity of dementia by assessing cognitive functions.
The importance of assessing cognitive functioning in brain tumour patients has been recognised and cognitive endpoints are added more frequently by cooperative groups including the EORTC Brain Tumour Group.
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