Prior to model development, we assessed all variables for missing values.
All reviews were performed according to a structured protocol that assessed all variables in the Rome, NY, ARA, Mexico, and Netherlands classification criteria, which are listed in Table 1.
Z-scores for BMI and height-for-age were calculated using WHO growth standards We assessed all variables thought to be potentially correlated with depression based on previously published research.
We assessed all variables for collinearity and removed median household income, average household income, median household effective buying power and average effective buying power from the analysis due to high collinearity with per capita income.
While the MindEdge study doesn't assess all these important variables that are key indicators for leadership capacity, it does alert us to the need for attention to and focused training in digital literacy, possibly even more important for older professionals and leaders than for millennials.
Despite the possible intrinsic data overfitting, the employment of logistic models, which assess all the combination among the variables analysed, reduce biases related to the selection of group comparisons.
By assessing all three variables within a single sample, the present study is able to provide a more direct evaluation of the putative neurobiological mechanisms that are believed to underlie the observed volumetric decreases in HPA-axis regulatory regions in MDD.
Third, due to the retrospective nature of the study, we were limited not only by the completeness of documentation by the treating physician but were also not able to assess all the variables (for example, relative bradycardia).
A Kolmogorov-Smirnov test was done to assess all the variables for normality.
We will assess all these variables and questionnaires at baseline, 6, 12 and 18 months.
