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This makes rodent models an efficient means for determining mechanisms, assessing variables, and screening drugs, biologics, devices and methods for further investigations in large animal models.
T-tests were used to identify differences at baseline in the assessed variables between N+IR and N-IR as well as O+IR and O-IR.
We assessed variables for multicollinearity and found that no pairs of predictors included in our model were highly correlated.
The process modelling confirmed that quadratic models were adequate to explain the behaviour of the assessed variables (R2 ≥ 0.94 and Q2 ≥ 0.75).
We did not find any significant relationship between still births and the assessed variables of interest either at the individual or district levels.
Our proposed methods and analytical strategies can be used to assess variable stability and reproducibility and hence may lead to more robust models with favorable predictive performance.
Random Forests (RF) were used to predict 8- and 24-week outcomes and to assess variable importance [35].
Many studies assessed multiple variables and outcomes and therefore the impact of multiple comparisons is a concern in this general area of research.
Standardized data collection assessed sociodemographic variables and previous and current ARV treatment.
The qualitative and quantitative analyses assessed different variables and were done in different countries.
Normality of variables was assessed and variables transformed as required.
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