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Medical and medication history, smoking status (current-, ex-, or non-smoker), alcohol consumption (g/day), regular exercise (≥ once per week), and education status were assessed using the same standard questionnaire in 2003 and 2008.
Medical and medication history, smoking status (current, ex-, or nonsmoker), alcohol drinking (≥3 times per week), and physical activity (≥3 times per week) were assessed using the same standard questionnaires in 2002 and 2005.
It comprised a knowledge test of similar format and standard, and the same two clinical scenarios, assessed using the same criteria.
All participants were assessed using the same protocol and were evaluated by a single observer (rheumatologist) using the gold standard method for case ascertainment, which is also a relevant advantage of this research.
The quality of the 6 samples was also assessed using the same methods.
Their texture was assessed using the same device.
At all visits lymphoedema was assessed using the same protocol.
Each comorbidity was also assessed using the same control variables.
All participants were assessed using the same battery of neurocognitive tests and in the same order.
The stability of the method is also assessed using the standard fourth-order Runge Kutta algorithm.
The staining of the cotton cloths were assessed using the standard gray scale for staining.
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