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Risk of bias was assessed using the principles published by the NHS Centre for Reviews and Dissemination [ 17], and the Cochrane Handbook of Systematic Reviews for Interventions [ 18].
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Once the anterior and lateral surfaces have been scanned, the patient is asked to sit up and the scanning zones on the posterior surface are assessed using the same principles.
Striatal volume was also assessed using the Cavalieri principle (Gundersen and Jensen, 1987).
The last-observation-carried-forward (LOCF) principle was used so that the primary endpoint could be assessed using the full MITT population (Fig. 1).
Dementia severity was assessed using the CDR.
Protein concentrations were assessed using the Pierce ™ BCA Protein Assay Kit
Apathy was assessed using the Neuropsychiatric Inventory.
Subjective sleepiness was assessed using the Stanford Sleepiness Scale.
Cognition was assessed using the MATRICS Consensus Cognitive Battery (MCCB).
Depression was assessed using the MADRS [22].
Factorial validity of the scales was assessed using principle components analysis.
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