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Risk of bias was assessed using one of two approaches, depending on study design.
Each lifestyle factor was assessed using one or two questions regarding behaviour while on night shift.
The inter group variation was assessed using one way analysis of variance (ANOVA) followed by Fischer's LSD test.
Descriptive norm was assessed using one item.
Significance was assessed using one way analysis of variance.
Response to TMZ and TMZ analogues between groups was assessed using one way ANOVA.
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The effect of scanner on MRI measures was assessed using one-way ANOVAs.
Effect of pacing on these variables was assessed using one-way repeated measures ANOVA.
Group differences were assessed using one-way analysis of variance (ANOVA) followed by the post-hoc Tukey honestly significant difference test.
Potential demographic differences between groups were assessed using one-way ANOVA and non-parametric Kruskal-Wallis test, in Minitab v.16 (Pennsylvania State University, State College, PA, USA).
Differences between groups were assessed using one-way ANOVA.
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