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Changes in the sBP, HR, EF, and SVR values were assessed using a repeated measures ANOVA, paired t test, or Wilcoxon signed-rank test.
The genotypic effect of a variant on the change over time in the CDR sum of boxes was assessed using a repeated measures mixed model, with covariates of baseline CDR sum of boxes, baseline MMSE, sex, age at baseline and APOE4 status, with genotype and the genotype*time interaction as the factors of primary interest.
Statistical significance was assessed using a Repeated Measures ANOVA followed by Bonferroni's multiple comparison test.
Trends in DASH scores among the different time points will be assessed using a repeated measures ANOVA.
When assessed using a repeated measures ANOVA, DF and DHF groups differ highly significantly with p<0.0001.
Possible differences in LTP were assessed using a repeated measures ANOVA followed by post-hoc pair-wise comparison with Tukey's t test.
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Statistical differences were assessed using a repeated-measure two-way ANOVA [35] with the sample encoding instruction ('fixate' and 'saccade') and the distance (eight spatial intervals between the sample dots from 2 to 16 deg) as main factors.
Changes in renal and systemic hemodynamic function in response to the DRI and DRI plus ACEi combination were assessed using a repeated-measures ANOVA.
Among participants in the CGM group, change in the amount of CGM use over time was assessed using a repeated-measures regression model based on van der Waerden transformed scores.
Analysis of treatment difference for total daily insulin dose was assessed using a repeated-measures analysis model with terms for treatment, country, gender, time (visit) and treatment-by-time (visit).
As all measured amplitude and latency values were distributed normally (D'Agostino-Pearson normality test), differences in latency and amplitude between the nine ISI categories were assessed using a repeated-measure one-way ANOVA.
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