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► The variability inherent in the fatigue life was assessed using a random field model.

The statistical significance of CS was assessed using a random sampling method [ 43] (Cournac and Koszul, unpublished).

The variance in neurobehavioral outcomes, assessed using a random effects model, was significantly associated within schools and classrooms, indicating correlation.

The rate of increase in reticulocyte counts (up to day 7) and recovery (from day 7 to day 63) was assessed using a random effects model.

The relationship between TV-1106 plasma concentration and the change in (baseline and placebo adjusted) QTcF interval was assessed using a random intercept mixed-effects linear regression model.

Although under-reporting might not have been completely avoided, the validity of the responses concerning sexual experience was assessed using a random response technique and considerable effort was made to put the respondents at ease, particularly for sensitive questions.

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For the meta-analysis, effect sizes (ESs) with 95% confidence interval (CI) were calculated and heterogeneity was assessed using a random-effects model.

All pooled data were assessed using a random-effects model with an inverse variance method.

Inter-reviewer reliability was assessed using a 1% random sample of reviews to calculate a kappa statistic.

The statistical significance of the main intervention effects was assessed using a multiple, random effects logistic regression model, adjusting for the other intervention and five covariates (age, gender, GP's practice, previous invitation, inclusion or not of a GP's signature) (Green et al, 2002; McAlister et al, 2003; Montgomery et al, 2003).

Agreement among experts assessing AWR will be assessed using a two-way random effects intraclass correlation (ICC) coefficient for absolute agreement using the metric: no = 0, maybe = 1, yes = 2. Apart from assessment of AWR, all other significance testing will be two-sided and a P value less than 0.05 will be considered to indicate statistical significance.

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