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Linearity was assessed using a residual plot.

The categorical data were assessed using a chi-square test.

Retention capacity was assessed using a noninvasive fluorescence imaging system.

Size distribution was assessed using a Malvern instrument.

and spore density was assessed using a cytometer (Neubauer).

Categorical data were assessed using a Chi-square test.

Finally, uncertainty was assessed using a probabilistic sensitivity analysis (PSA).

Descriptive statistics by diuretic resistance assessed using a FeNa <0.2%.

Data distribution was assessed using a Kolmogorov Smirnov test.

Clinical and demographic data were assessed using a standardized protocol.

Intervention resistance to corticosteroids was assessed using a skin test.

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