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In a previous study, DNP plasmids encoding for reporter genes had been successful in generating long-term reporter transgene activity in the striatum (>365 days) and in this study produced sustained GDNF activity at the longest assessed time point (6 months).
However, in response to IL-4, the M1 associated factors IL-6, TNFα, and CCL5 were not increased at any assessed time point.
When CYFRA 21-1 wanalysedsed as continuous variable the strongest prognostic information was again based on the absolute CYFRA 21-1 vatueacht eassessedssed time point and not on the marker kinetics during treatment (see Table 4).
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These same diagnoses criteria were used for all assessed time points.
The addition of basic demographic information did not change the results at any of the assessed time points.
Mean observed bevacizumab concentrations were generally less than those predicted from simulations with overlapping 95%-confidence intervals at each of the assessed time points.
At all assessed time points, little or no ATF-3 expression was observed, with a maximum of two ATF-3-positive cells per DRG section.
Absolute levels of CYFRA 21-1, CA 19-9 and CEA showed an excellent correlation with treatment response at almost all assessed time points (see Table 2).
Furthermore, for the assessed time points, no abnormal tissue organization could be seen at the implantation sites, apart from the necessary wound healing.
CYFRA 21-1 showed a strong correlation with TTP and OS at all assessed time points in the univariate evaluation (P<0.0001, for details see Table 4).
Interestingly, the main determinant for response was the absolute CYFRA 21-1 level (at any of the assessed time points) rather than the kinetics during chemotherapy (see Table 2); an observation that also holds true for CA 19-9 and CEA.
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CEO of Professional Science Editing for Scientists @ prosciediting.com