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Patients with progression of disease – defined as a change in bidimensional tumour measurement from randomisation of ⩾25%, or clinically assessed progression – at any time after randomisation, were unblinded.
We assessed progression of radiological damage in the placebo and active treatment arms by calculating the difference between the 1-year and baseline scores (ΔTGSS).
This delay means there is a need for more sensitive measures that can detect the process of bone and cartilage damage, which may therefore be predictive of radiographically assessed progression of joint damage.
We therefore assessed progression through the second meiotic division using ovulated eggs obtained from females that were mated to aspermic males, and were then activated in vitro with SrCl2.
These two trials show how TNF antagonists have raised the standard of treating patients with RA on the basis of their shown ability to produce significant improvements in clinical parameters (such as ACR response) and to retard the radiographically assessed progression of joint damage.
In a sensitivity analysis, we dichotomised patients in the placebo and TCZ groups into those who had normalised their CRP and those who had not, and assessed progression of joint damage in these patients; in this analysis we evaluated the two tocilizumab groups separately, because it had been established that CRP normalises less frequently at 4 mg/kg than 8 mg/kg.
Similar(54)
Primary end point was independently assessed progression-free survival.
Radiological follow-up with six monthly ultrasound or CT scans should be mandatory to assess progression of the aneurysm.
Characteristic parameters for determining the challenge level and to assess progression are also defined in this phase.
Prospectively, the study will assess progression of subclinical and overt EVD, including risk factor outcome relation differences across communities.
An argument for the importance of using visual function techniques to assess progression in an individual patient is given.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com