Mixer design is still very empirical and is not based on assessed methodologies.
Simulated records were used to assess methodology.
To assess methodology, results and interpretation of oncology randomised controlled trials closed early for benefit (RCTCEB).
To assess methodology, 13 investigators (10 physicians, one pathologist, one biostatistician and one biologist) read each publication independently, and scored them according to the ELCWP scoring scale.
10 No guidance exists to assess methodologies that lead to different results.
Medical technologies and drugs are assessed using methodology favouring the statistical power of large numbers and certain study designs.
Two reviewers independently determined the eligibility of studies, assessed the methodology of included studies and extracted the data.
Nonrandomised studies were assessed on methodology and sampling strategy but could not be assessed for quality using any validated grading systems.
22 Two reviewers (CM and IJO) independently determined the eligibility of studies, assessed the methodology of included studies and extracted the data.
We have first assessed this methodology with phantom studies before applying it in more realistic in vivo proof-of-principle studies.
