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First, the complexity of the major loop is assessed in Steps 1 and 4, and then the QP loop is evaluated separately.
Assessment of percentages of positive cells was performed across the entire sample in a blinded fashion upon light microscopy by two investigators and is given as the mean of both percentages assessed in steps of 5%.Percentages of staining refer to epithelial/tumour cells within samples.
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These recommendations were further assessed in step 3.
As the suitability for reformulation into the EORTC item style already had been assessed in step two, no items were deleted in this step.
For the third hypothesis, the predictors of caregivers' QOL (based on caregivers' general facet on health & QOL as dependent variable) were assessed in step-wise regression analysis.
We conducted a review of therapeutic methods available to change determinants (assessed in step 1), reach objectives (formulated in step 2), and confront ineffective behaviours of both patients and professionals [search strategy and results available from the 1st author].
We also evaluated six methods (MDR, FIM, BEAM, MECPM, SH and LR) in Step 3 - we do not evaluate IG and LRIT, because, by design, they only output multi-locus interaction candidates, and thus are inappropriate to be assessed in Step 3's main effect evaluation.
Depressive symptoms are assessed in 2 steps.
Potential multicollinearity was assessed in two steps.
Genes duplicated in N. furzeri were assessed in two steps.
A subgroup analysis was carried out, excluding the states in which the values were assessed in two steps.
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