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A total of 2257 transfused patients were assessed for inclusion.
Titles that appeared relevant were assessed for inclusion.
Of these, 48 studies were carefully inspected and references were obtained and assessed for inclusion.
Studies using other methods were also assessed for inclusion in this narrative summary.
Of 77 patients assessed for inclusion, only 45 had mderate or severe pain.
The publications from phase II were then retrieved in full text and assessed for inclusion of domain abstraction in phase III by two independent reviewers.
All studies that evaluated weight-estimation methodologies were assessed for inclusion into the study by two separate investigators (MW and LG).
Each potentially relevant study located in the search was obtained as a full article and was independently assessed for inclusion by two review authors.
Each citation was assessed for inclusion and quality using a modified version of the 'Quality Index' and a novel inclusion/exclusion criteria checklist by two independent reviewers.
Publications assessed for inclusion in Cochrane Reviews were included.
Reference lists of studies assessed for inclusion were also searched.
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