The studies also vary in experimental design and model systems used to assess end points relevant to diabetes as a health effect.
Only 2 of the 13 studies assessing end points related to T1D following exposure during pregnancy reported findings consistent with an association (Sipetic et al. 2005; Wahlberg et al. 2011).
The list was concealed from the clinicians enrolling patients and assessing end-points (MPL, MU), as well as from the parents, until the end of the study.
The study may also have been subject to bias, being open-label in design with investigator-assessed end points.
Ideally, human data have been obtained from experimental studies with controlled exposures and well-assessed end points of sensory-mediated defense mechanisms/reflexes such as eyeblink frequency.
Emergency department (ED) visits for a combined cardiovascular (CVD) and respiratory disease (RD) group were assessed as end points.
The commonly assessed neurodevelopmental end points include intelligence quotient (IQ), memory, language, gross and fine motor skills, attention, executive functions, and behavior.
23 In adult patients, assessed effectiveness end points include the effect of Norditropin® on body weight and composition, quality of life, blood chemistry (including IGF-I, pituitary hormones and sex hormones routinely, and thyroid and adrenal hormones if necessary).
The effect of widespread use of safe and effective probiotic products on society-wide economic and quality-of-life indicators should be assessed with end points such as reduction of common infectious diseases in developing and developed nations.
We used a multistate model which uses transition paths to simultaneously assess multiple end points.
