Sentence examples for assessed compounds from inspiring English sources

A principle challenge faced by the information gleaned from phenotypic screening is that many of the assessed compounds remain orphan ligands, as the respective mode-of-action (MOA) remains undetermined in the first instance [1].

The sensitivity improvement of most of the assessed compounds ranged from 20 to 27, while the signal enhancement effect for aspartic and glutamic acids was found to be 32 and 31, respectively.

The HTS assay assessed compounds at 10 μM for 6 8 h in Chinese hamster ovary (CHO) K1 cells containing luciferase constructs that individually reported on Chop activation or Xbp1 splicing.

Among four compounds assessed, compound 2 demonstrated highest specific to NSB ratio (2.2).

This may be sufficient to assess compounds that primarily influence biosynthesis and/or secretion, but it would not allow assessment of any later step in collagen matrix formation.

Here, we built a new computational method to simply assess compounds and herbs in FFDS in treating pain.

The proposed sp7:luciferase zebrafish scale model is unique, powerful and efficient new tool to assess compounds with osteogenic effects, prior to further testing in rodents.

The formation of tube like vessels on Matrigel can therefore be used to assess compounds that either stimulate or inhibit angiogenesis (Ponce, 2001).

Standard genotoxicity test batteries have been adopted by the International Congress for Harmonization Guidelines, the gold standard for assessing compounds used in clinical trials of human subjects (ICH Steering Committee 2008).

Attenuation of neutrophil migration may be of benefit in treating hyperacute stroke, but previous trials assessing compounds that inhibit neutrophilic function have been ineffective (Krams et al., 2003).

Overall this study suggests that relatively low concentrations of organic solvents can impact upon the biotransformation of certain xenobiotics in zebrafish larvae, and that this warrants consideration when assessing compounds for metabolism and toxicity in this species.