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The suitability of using a general linear model was assessed by generating a histogram of residuals and further residual (on the y axis) plots of fitted values and expected normal quantiles.

The generality of this approach to antibody protein conjugation was assessed by generating similar fusions with a human antibody against the HER2/neu receptor, a common breast and ovarian cancer marker and target of the clinically approved antibody drug Herceptin.

For each CR50 and CS50 observation, IC90 results were further assessed by generating dose response curves of representative strain:drug combinations (Supplementary Fig. 3).

The effect of spatial interpolation errors was assessed by generating 100 realizations of the land characteristics by Sequential Gaussian Simulation.

The effect of model (in accuracy was assessed by generating 100 perturbations using a variance-covariance error matrix filled using independent measurements from 1953 CE.

The proposed methodology is assessed by generating different layer-wise and equivalent single layer models for the analysis of thick magneto-electro-elastic plates and comparing their solution against available three-dimensional analytic results.

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We evaluated model accuracy and further assessed utility by generating report rankings that represented a prioritized report review process.Our random forest model showed the best performance in report ranking and accuracy, with an area under the receiver operating characteristic curve of 0.66.

In the neutrality test, we assessed significance by generating null distributions from 10,000 coalescent simulations; significantly negative values indicated population expansion.

We assessed statistical significance by generating 1000 permutations of each of the 70 ICNs by reassigning the coordinates of each voxel randomly.

The pattern reproduction of SMIM model is assessed by scanning the generated model, and the ratio of pattern reproduction number to that of reference model (i.e. the similarity) is around 97.28%.

GC activity in vitro was assessed by measuring cGMP generated from GTP in the presence of 10 µg purified protein, 50 mM Tris-HCl (pH 7.5), 2 mM isobutyl methylxanthine (IBMX), 5 mM Mg2+ and/or 5 mM Mn2+ and 1 mM GTP [39].

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