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The compounds were removed according to the rate of their dissimilarity from the rest of the training set, which was assessed by the applicability domain methods.
The studies lacked validation and had high risk of bias and poor clinical applicability as assessed by two independent reviewers using a modified quality assessment tool.
Consistency and applicability was assessed by comparing each reviewer's original rating with the consensus.
To address this and other short comings a number of two-phase flow models have been investigated and their applicability and accuracy assessed by comparison with experiments in the literature for a vertical pipe flow with relatively high mass loadings of the discrete phase.
The applicability of the method was assessed by means of recovery studies and satisfactory values for all compounds were attained.
Our results indicate that a given applicability domain needs to be assessed by the use of more than one external dataset to investigate the robustness of the AD.
The applicability of these markers was assessed by genotyping 57 individuals from two natural populations.
The clinical applicability of these assays was assessed by analyzing 100 colorectal cancer samples, for which KRAS mutation status has been evaluated by the commercially available TheraScreen® KRAS mutation kit.
Nevertheless, external validity of our model is a crucial prerequisite to clinical applicability, and can only be assessed by confirming results in a reasonably large independent validation cohort with an adequate follow-up period.
The applicability of the numerical model was assessed by calibration with field measurements obtained from a longwall mine site.
The applicability of the aptasensor was successfully assessed by determination of epirubicin in a human blood serum sample.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com