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Clinical outcomes will be assessed at entry and at 6 months and 1 year.
Weight and electrocardiogram were assessed at entry and at the final visit.
Left ventricular ejection fraction, when assessed at entry and at any time during the hospital stay was recorded.
However, the study of Hawkins et al. [ 50] in which participants were assessed at entry and at 6 and 12 months failed to prove a decline of the cognitive functioning during the period of transition to psychosis.
The presence of a significant problem in various clinical and social domains was assessed at entry and followed up through the Needs For Care Assessment Schedule (NFCAS), a standardised procedure created by Brewin [ 24, 25], which was designed to improve care planning for such patients and has been extensively used in various circumstances [ 26- 28].
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At each site and for Usual Care and PCRM-CI groups, mobility is to be assessed at entry into rehab and at discharge from rehab.
Four major strengths of this study are that there was a long follow-up period, the participants were unselected, fitness was assessed at entry into rehabilitation, and all the data were collected in routine clinical practice by one physiotherapist (ST) using a consistent fitness delivery programme.
All patients were assessed at entry into the trial and regularly during the period of the trial.
The patients' academic achievement, including behavioral problems (many/some or none), were assessed at entry together with hopelessness (one item yes/no) and alcohol and drug misuse in a semi-structured interview by a psychiatrist.
The salivary cortisol awakening response, all day salivary cortisol, and scale scores on sleep, pain, aggression, quality of life, and perceived stress assessed at entry were compared to values following 4 weeks of intervention.
Socio-demographic and drug use characteristics, and markers of viral infections were assessed at entry.
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