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Patient-derived primary skin fibroblasts were used to assess the potency of a new library of chromanyl-based compounds to reduce ROS levels and protect cells against redox-stress.
HeLa (cervical), U-87 (glioblastoma), Panc (pancreatic) and MCF-7 (breast) were used to assess the potency of the synthesized compounds as anticancer agents.
Moreover it constitutes an attractive technology for drug discovery programs, for high content, high throughput screening assays, to assess the potency of new hits and optimize lead compounds, whilst also serving to characterize drugs developed through rational design.
Finally, we wanted to assess the potency of our method when dealing with real-world images.
However, based on the knowledge that VEGF targets VEGF receptor-2 (VEGFR-2, expressed mainly on vascular endothelial cells) and subsequently activates calcineurin-nuclear factor of activated T cell (NFAT) signaling, a reporter gene assay (using engineered NFAT-RE-luc2P/KDR HEK293 cell line) was developed to assess the potency of VEGF-specific mAb.
Who needs the endless inanity of Twitter when you've got a group of likeminded individuals working together to objectively assess the potency of a recently pressed batch of Yellow Minions?
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Serial twofold dilutions of the two preparations in PBS are used to assess the potencies of the two preparations in chessboard PHA tests using known positive rinderpest antigen.
This method should be useful for quantitatively assessing the potency of vaccines and the longevity of B cell immunological memory to various vaccines or infectious diseases.
Emboldened, I went to talk to Wayne Saunders, a D.C. resident who had a fancy Willy Wonka machine on his table for assessing the potency of marijuana.
This assay assesses the potency of antibiotics by determining the minimal concentration at which no visible bacterial growth can be observed.
The use of a reporter gene assay offers a rapid and reliable means of quantitatively assessing the potency and specificity of RNAi.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com