Sentence examples for assess the functional effects from inspiring English sources

In one arm of the screen we used electrophysiology to assess the functional effects of the library compounds on full-length EAG1 channels.

In this study, we used recombinant Wnt3a to assess the functional effects of canonical Wnt signaling in epithelial cells and fibroblasts.

Systematic studies using both in vitro and in vivo assays to assess the functional effects of mutations that alter the sequence, but preserve (or destroy) the conserved RNA structural motif, will be required to fully evaluate its potential biological significance.

In order to assess the functional effects of different action potential (AP) kinetics in VSD imaging in cultured cells, we have simulated an 'mmature'and a 'mature' Na+-current (INa) in cultured cells using the dynamic clamp technique.

To assess the functional effects of aptamers, U87MG (300 000 cells per 3.5-cm plate) were serum starved for 2 hs and then treated with the RNA aptamers or the starting RNA G0 pool prior subjected to a short denaturation-renaturation step.

To further assess the functional effects of MD on these two mouse strains an echocardiography time-course was conducted.

Further studies are required to assess the functional effect of these putative causal mutations.

We also performed ERGs in order to assess the functional effect of I-R injury on retinal light responses and a potential protective effect of NPY.

To assess the functional effect of CTLA4-KDEL and IDO expression on the ability of DCs to stimulate allogeneic T cells, BALB/c DCs were transduced, activated with LPS and then used to stimulate fully MHC-disparate C3H/He CD4+ T cells.

To assess the functional effect of SD-associated RGS17 and RGS20 variants on gene expression, whole genome Illumina lymphoblastoid cell line gene expression data from 120 unrelated HapMap individuals (60 from the CEU population and 60 from the YRI population) were extracted from the GSE6536 series data set in the Gene Expression Omnibus (GEO) site (http://www.ncbi.nlm.nih.gov/geo).nih.gov/geo

However, while simply using a null mutant or knocking down the expression of a gene of interest (e.g., using RNA interference) in such a model system may initially help us to understand its larger role in development, such methods do not allow us to assess the functional effect of natural variation in that gene.