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Further assessment is warranted to identify the cartilage proteins containing this modification and to assess the functional consequences and biomarker applications of this analyte in OA.
We designed two complementary field experiments to assess the functional consequences of beekeeping on plant reproductive success.
The usual imaging techniques providing only limited information, there is an unmet need for methods, firstly, to monitor in real time the functional status of the Spinal Cord (SC) and, secondly, to assess the functional consequences of the SC Injuries (SCI) and the effect of therapeutic interventions.
The objective of the study was to determine whether cross-talk occurs between estrogen receptors (ERs) and nuclear factor-kappa-B (NF-κB), to assess the functional consequences of such an ER/NF-κB interaction, and to identify other unknown regulatory proteins that may participate in the NF-κB transcriptional complex.
To assess the functional consequences of this broad Wg distribution, we have devised a means of perturbing endocytosis in spatially restricted domains within the embryo.
We took advantage of tools developed for metabolomics studies to assess the functional consequences of the network topology [20], [21].
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To assess the functional consequence of septin-depletion on bacterial entry, we employed the classical gentamicin survival assay [33].
To assess the functional consequence of MEK1 p.D67N, this amino acid substitution was analyzed by SIFT and found to be functionally affected.
To assess the functional consequence of depressed TGF-beta signaling, we blocked TGF-beta by adenoviral overexpression of the TGF-beta inhibitor LAP two days after IL-1 insult.
To assess the functional consequence of the G375D substitution on GABAergic synapses, we recorded miniature inhibitory postsynaptic currents (mIPSCs) in hippocampal neurons expressing GFP‐gephyrin or GFP‐G375D (Fig 4F).
Michaud et al. used conditionally immortalized mouse podocytes infected with adenoviral constructs containing WT or K256E murine Actn4 to assess the functional consequence of mutations on subcellular localization, adhesion, spreading, migration, and formation of foot process-like peripheral projections [ 65].
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