Exact(8)
While further evaluations may be needed to assess specificity and confounding factors of these assessment tools, the results may be a matter for consideration in future IOL design efforts.
To assess specificity, sensitivity, reliability, and reproducibility, we analyzed DNA from 120 primary adult AMLs and compared DHPLC results with immunohistochemistry and sequencing.
To assess specificity of the radiotracer, a separate group of animals was co-administered [68Ga(THP-TATE)] and TATE peptide, followed by scanning, euthanasia and ex vivo organ counting 1 h PI.
The following aspects will be considered: mechanisms by which AOs exert their effects, types of animal model system used, detection of antisense action, effects of AO design and delivery characteristics, non-antisense effects and toxicological properties, controls used in antisense studies to assess specificity, and our results (failures and successes).
To assess specificity, amplification products were subjected to melting curve analysis and gel electrophoresis.
Immunocytochemistry was performed to assess specificity of Cre protein expression to oligodendrocytes.
The need to assess specificity of antigen recognition led us to focus on adaptive immune responses of T cells.
To further assess specificity, we asked whether E-cadherin and p120 could be crosslinked under conditions where physical interaction is selectively uncoupled (Figure 2b).
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