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This manuscript summarises our attempts to identify such an antigenomic molecule, to localise this molecule to mitochondria and to assess its function in whole cells.
To assess its function, ERK3 was knocked down by microinjection of ERK3 MO.
The development of a new class of calpain inhibitors that interact with domains outside of the catalytic site of calpain may provide greater specificity, which may allow to more precisely assess its function [30].
In this study we analysed the expression of PAX3 across the spectrum of melanocytic cells, from normal melanocytes to cells of benign and malignant lesions to better assess its function in these various tissues.
As very little data have been published with regard to this semaphorin, more studies are necessary to assess its function in tumorigenesis.
To assess its function in cartilage, BMP-2 was overexpressed in healthy murine knee joints and the effects on proteoglycan (PG) synthesis and degradation were evaluated.
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To determine if LRR1 is required for XA21-mediated immunity, we assessed its function in rice plants in the presence and absence of XA21.
The authors went on to analyze this human mutation in a zebrafish model, and assessed its function in live hearts.
After showing the key role of JAK in TNF-induced caspase-1 expression and activity, we assessed its function on maturation of IL-18.
Few studies have assessed its role in functioning in schizophrenia.
It will be interesting to characterize the P. pacifica CPI1 homolog in order to assess its precise function, as well as the types of sterols produced by P. pacifica.
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