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Optimization of clinical trial design should include the choice of clinical end points which provide mechanistic proof-of-concept and also reflect clinical benefits (e.g., surrogates to assess increased collateral flow reserve, such as myocardial perfusion imaging).
Colour and power Doppler may be utilised to assess increased vascularisation, a marker of active inflammation, to differentiate between active and quiescent disease [14].
Another EDA study of plant neuroactivity applied similar bioassays, in combination with larvae whole-mount in situ hybridization to assess increased brain c-fos gene expression as an indicator of seizure onset and brain damage [34].
On two occasions participants accidentally mentioned their treatment allocation status to the assessor, and in other two occasions it was deemed necessary to break the blinding because of the need to assess increased depressive symptoms during treatment.
We applied several questionnaires to assess increased daytime sleepiness and fatigue as well as depression.
Similarly, when a chemical is found to be antiandrogenic, the current science would support using the data to assess increased risk of developmental effects.
Similar(51)
This was particularly challenging for neurodevelopmental assessments; every additional developmental domain assessed increased the risk that children would be excessively fatigued.
The 18 min utes assessed increased to 375 the Stanley Cup mark for penal ty minutes by two teams in one series.
We assessed increased precipitation during spring season but the summer precipitation decreased substantially in all climate change scenarios.
Animal models assessing increased exposure to artificial physical elements characteristic of urban settings, as well as exposure to unnatural sources of light for extended durations, are reviewed.
For instance, digital infrared thermography is an imaging modality assessing increased superficial temperature related to varicocele [63].
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