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Thus, demethylation of Tregs may be a very reliable and specific marker useful and feasible to assess in large field studies in cord blood, however not examined yet.
For international multicenter population studies assessing Tregs for example in the development of allergic diseases in early childhood, it is critical to use a parameter for Tregs, which is specific and at the same time feasible to assess in large field studies when storage and transport conditions do not allow immediate assessment of Tregs by flow cytometry.
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They specifically note the importance of tacit and socially complex knowledge resources as critical in the PMI process distinctions that are important in practice but difficult to assess in larger scale PMI studies.
The severity and clinical implications of these adhesions should be assessed in large prospective trials.
The diagnostic yield of EUS-guided FNA (EUS-FNA) of suspected GI stromal tumors (GIST) has not been assessed in large series.
The efficacy of cervical nVNS (gammaCore®) in primary headache prevention or acute therapy is currently being assessed in large studies.
However, the genetic similarity between pig and human has not been assessed in large, systematic studies.
Dexamethasone, ranibizumab and aflibercept have been assessed in large commercially funded trials.
The lifetime prevalence of BED has been assessed in large population samples in the US [ 45, 47] and Europe [ 46].
Knowledge and comfort with IPV identification has been assessed in large scale surveys and smaller qualitative studies.
The clinical significance of different prognostic factors is best assessed in large, cooperative, quality-controlled multi-centre prospective clinical trials.
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