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The studies also vary in experimental design and model systems used to assess end points relevant to diabetes as a health effect.
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We assessed end points ≥1 year after a negative Ga SPECT/CT result (for those who did not receive antibiotic therapy) or the start of antibiotic treatment (for those who received it).
Only 2 of the 13 studies assessing end points related to T1D following exposure during pregnancy reported findings consistent with an association (Sipetic et al. 2005; Wahlberg et al. 2011).
The list was concealed from the clinicians enrolling patients and assessing end-points (MPL, MU), as well as from the parents, until the end of the study.
We used a multistate model which uses transition paths to simultaneously assess multiple end points.
The need for studies evaluating the effects of CV imaging that assess appropriate end points is critical to address continued concerns over the lack of well-designed clinical studies.
Studies were not primarily designed to assess these end points.
This allows us to assess the end points of the study in different template scenarios.
We used angiography, immunohistochemistry, intravital microscopy and qPCR to assess safety end points and the distribution of injected cells.
We did not assess efficacy end points in our study, as patients could be treated in either (neo)adjuvant or metastatic setting.
Of the animal tests that were conducted, combined protocols that could assess multiple end points in a single test significantly reduced animal use.
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