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The primary end point of the phase II part of the trial was to assess confirmed response rate using International Myeloma Working Group Uniform Response criteria.
A minimum of three visits (including baseline) at which an EDSS was formally recorded were, by definition, required to be able to assess confirmed disability progression.
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A cassette of molecular markers of differentiation was also assessed confirming the differentiation status of both cell populations (see Figure S1).
The levels of total EGFR in these cells were assessed confirming published data (Supplementary Figure 1).
The properties of the experimental design were assessed, confirming that the design was orthogonal (both in terms of profiles and tasks), 100% D-Optimal for main effects in a paired experiment, and that level balance and zero overlap were achieved.
A minimum of three visits per patient spanning a minimum 9 months, with full EDSS assessment was required to assess first confirmed 3-month disability worsening.
Experiment on three benchmark datasets (DUC 2005, 2006, and 2007) assess and confirm the effectiveness of the proposed framework and algorithms.
The usability and performance of this modified Jameson Cell was firstly assessed and confirmed on flotation of spodumene by a pilot-scale plant.
All positive findings were re-assessed and confirmed by a single uveitis specialist.
The effect of SLED and PD on AKI needs to be better assessed and confirmed by high-quality studies.
This prompted us to use CDT as complementary test in order to assess and confirm the ESBL-status.
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