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Cochran-Armitage trend test was used to assess a trend in the proportion of farm equipment crashes across categories for traffic volume.
It should be noted that no authors used statistical methods to assess a trend for ordinal variables; therefore it is our interpretation that no dose gradient is apparent.
Kaplan-Meier survival analysis was performed and a log-rank test was used to assess a trend of survivor's function across four quartiles of TWIST1 mRNA expression levels.
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We assessed a trend for more rapid tumour growth in younger patients and found the initial volume of the tumour (rho = 0.63) and of the soft tissue component (rho = 074) to be significantly related to the growth rate.
In a supplementary analysis, dose was included as a covariate to assess a linear trend with dose.
A weighted least-squares technique was used to assess a linear trend in the annual hospitalization rate for ulcer types during the 8-year study period of 1998 2005; the independent variable was year and the dependent variable was the rate.
To assess a linear trend of the association between endometriosis risk and PCB concentration, we also fit models using the natural log-transformed continuous values for each PCB congener.
All of the studies retrieved were grouped per publication decade, and the weighted mean age of patients using LAIs was calculated for each decade to assess a possible trend.
In addition a chi-squared test was used to determine the statistical significance of differences in the prevalence estimates between boys and girls within each age group as well as to assess a linear trend in the prevalence estimates with increasing age for the seven countries with multiple age groups selected (Belgium, Greece, Ireland, Italy, Lithuania, Slovenia and Spain).
Because our dosing schedule includes multiple groups receiving either 2 or 3 visits per week (Groups 3 and 4 receive 2 doses per week and Groups 4 and 5 receive 3 doses per week), we will only be able to assess a linear trend of improvement in individuals in those pairs of groups.
To correct for multiple comparisons, a conservative Type I error level of 0.01 was used to assess significance; a trend was assumed if the Type I error level ≤0.10.
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