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Deputy Commissioner Craig Mackey told members of the London Assembly the problem could get worse.
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de novo assembly eliminated the problem with reads that may be mapped to spurious positions (mostly repeats or homologous regions) with mismatches being called SNPs.
Therefore, in order to fully exploit nanostructures for device applications through self-assembly, the problems of self-assembly adherent to the thin film forms need to be overcome.
CABOG can generate mis-assemblies, but the problem appears to be mitigated by inclusion of long-range mate data.
Reducing the coverage cutoff increased the amount of noise and the complexity of the assembly problem, thereby reducing the total number of full length assembled transcripts.
A worker at the assembly plant discovered the problem.
By aggressively localizing the assembly problem during the first stage, our method succeeds in assembling short, unpaired reads sampled from repetitive genomes.
In the presence of errors in the experimental data, the assembly problem is computationally challenging, and its solution may not lead to a unique reconstruct.
Owing to the complexity of the assembly problem, we do not yet have complete genome sequences.
To further reduce the complexity of the assembly problem, we classify all contigs as either long (more than 500 bp) or short and concentrate on ordering the long contigs correctly.
By doing this, we effectively localize the assembly problem and restrict the set of reads that any particular read can overlap.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com