Exact(3)
It is worth noting that GST-Ure2p 1-42 has a higher assembly propensity than free Ure2p 1-42.
Thus, the intrinsic assembly propensity of Ure2p prion domain into fibrils of amyloid nature appears to be abolished by its covalent association with the functional domain of the protein that leads to the generation of fibrils with high α-helical content.
Their exquisite NPC-typical sorting selectivity and strong intrinsic assembly propensity suggest that Nup98 FG phases can form in authentic NPCs and indeed account for the permeability properties of the pore.
Similar(57)
The results reported highlight some key structural properties that explain the self-assembly propensity of Peptide OP.
To validate the importance of sidechains in supramolecular architectural stabilization, herein this report describes the self-assembly propensities involving weak interactions in a series of model tripeptides Boc-Xaa-Aib-Yaa-OMe I IV, (where Xaa = 4-F-Phe/NMeSer/Ile & Yaa = Tyr in peptide I III respectively and Xaa = 4-F-Phe & Yaa = Ile in peptide IV) differing in terminal side chains.
Consideration of this result in conjunction with the use of explicit targeting for the keratin assembly illustrated a low propensity for PRICE to spuriously engage in off-target assembly work not supported by data.
On the basis of sequence analysis of amyloid and elastic proteins and extensive molecular dynamics simulations, it has been proposed that this type of substitution would result in a peptide with greater propensity for assembly into amyloid fibrils than elastic polymers.
Sequences of amino acids with high β-sheet propensities promote assembly into one-dimensional nanostructures in water.
Another advantage of our model is its ability to provide an estimate of the propensity of assemblies with different levels of symmetry breaking based on the kinetic equations derived from a statistical formalism based on molecular interaction [ 32, 69- 71].
As initially reported, microcapsule assembly was directed by the propensity of the gold nanoparticles to assemble at an oil water droplet interface to form a Pickering emulsion, leading to accumulation of capsule-forming materials and ultimately the formation of a flexible supramolecular nanocomposite skin.
The PSAM retained high conformational stability, suggesting that the flat β-strand of the Ile5 stretch primed for self-assembly is a low-energy conformation of the Ile5 stretch and rationalizing its high propensity for self-assembly.
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