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The unique mechanical properties of biological tissues arise from the exquisite multiscale hierarchical assembly of tissue macromolecules.
Although assembly approaches, such as bioprinting and directed assembly of tissue building blocks, are powerful tools for mimicking cellular organization of native tissues, one should bear in mind that cells are highly connected to their microenvironment and their fate changes with the spatiotemporal release of growth factors from their microenvironment.
RL carried out assembly of tissue microarrays.
This allows the assembly of tissue collections in TMA with variable magnifications.
Tumour tissue from paraffin blocks is collected centrally for formal pathology review and assembly of tissue micro arrays.
DB carried out assembly of tissue micro arrays and immunohistochemical stainings including evaluation and was involved in preparation of the manuscript.
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Rapid recovery of cell sheets is considered to be important as a basic technology for practical assembly of tissue-mimicking structures.
The work concerning the numerical simulation indicated that this chip could form fixed-length particle chains in perpendicular alignment to satisfy the structured assembly of tissues in the histological engineering application.
Eukaryotic cells possess a remarkable capacity to aggregate together and form into a clump, which is crucial for the assembly of tissues and nervous systems, embryonic development, and cellular communication.
Of the 60 cases where tissue was available, 2 cases had insufficient tumour tissue for DNA extraction or for a core to be taken for assembly of a tissue microarray (TMA) and a further single case had an extremely low DNA yield and insufficient material for tissue microarray.
However, fibril alignment is an important feature in many tissues that needs to be monitored for effective assembly of anisotropic tissue constructs.
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