Recent progresses in molecular and cellular biology have revealed the mechanisms that control the assembly of the nodes of Ranvier.
The second most connect hub is GLDN, a gene coding for gliomedin, a molecule well known for mediating heterotypic cell-cell adhesion and interacting with neurofascin-186 (NF186) and neuronal cell adhesion molecule (NrCAM) in the molecular assembly of the nodes of Ranvier in the peripheral nervous system [ 94, 95].
Schürmann's Ph.D. project was to implement an artificial neural network, an assembly of interconnected artificial nodes that process information according to a mathematical or computational model.
A neural network is an interconnected assembly of units or nodes known as artificial neurons, which simulates the function of a human nervous system.
(Rule 3) Link 5 indicates that the docking of receptor-cargo complexes on the peroxisomal membrane (node 16560) depends on the assembly of the peroxisomal membrane (node 45046).
For a network of a certain size we can evaluate its statistical significance based on the probability of its assembly from a random set of nodes the same size as the input list (see Additional File 1, Supplement Table S12).
Compared with normal tissues, primary cancerous colorectal tissues showed assembly of cortactin in lymph nodes, suggesting a close involvement of cortactin in metastasis of colorectal cancer cells.
We propose that transient contacts between the β- and γ-short arms are consolidated by the slower incorporation of an α-short arm, and that the conserved β5′ β6 loop of αLN domains has an important function in the cooperative assembly of the ternary αβγ nodes in the laminin network.
Then, actin polymerization induces the assembly of both actin bundles (node 8154) and a patch of cortical actin (node 10324).
The top panel of Figure 5 depicts the steady increase in mean volume of lymphoid tissues in the course of tumor progression, employing (1) three different peripheral lymph nodes (cervical (CLN), axillary (ALN) and inguinal (ILN)), (2) the assembly of 6 8 deep abdominal lymph nodes commonly referred to as the mesenteric node (MLN) and (3) the spleen (SPL).
Our approach consists of transformation of graphical representation describing relation between input components of assembly node and numbers of related product configurations into design matrix of coupled design.
