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Through these interactions, often mediated by IgFLN16 24, FLNs complex multiple partners in close proximity to one another, potentially enhancing signal transduction by aiding assembly of networks linking receptors with signaling proteins and the cytoskeleton [5].
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Novel developments in chemical analytics such as real-time mass spectrometry to follow the metabolism online, directed physical assembly of network members facilitating substrate channeling, and encapsulation forming biofunctional subunits enable a better control and potential for optimization.
The degree-weighted nature of PPI networks as well as the hub grouping present a quandary in that it implies that the assembly of these networks may be less biologically guided and more probabilistic in nature.
The assembly of these networks is controlled by electrostatic interactions between the phage pVIII major capsid proteins and the AgNPs.
Here, we investigated the impact of graphene on the formation and performance in the assembly of neural networks in neural stem cell (NSC) culture.
Thus, the formation of synaptic laminae is ultimately dispensable for the correct wiring of direction-selective tectal circuits, but it is crucial for the rapid assembly of these networks.
The assembly of the networks exhibited in Fig. 2 and Fig. 3 were initially loaded with only the differentially regulated genes from the respective datasets.
Its laminated structure, formed by a relatively small number of neuronal types, and its delayed postnatal development, have greatly facilitated experimental analyses aimed at understanding the function and developmental assembly of neuronal networks [4] [11].
The head region is required for assembly of IF networks [ 41, 46].
An enlightening demonstration of the power of epistasis for assembly of gene networks is for instance a reconstruction of a four-gene cell death pathway in C aenorhabditis elegans (Metzstein et al., 1998).
In vitro, we have used siRNA technology to knock down NG2 expression in human microvascular pericytes, followed by examination of the ability of these cells to interact with human endothelial cells in the assembly of vascular networks.
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