Through these interactions, often mediated by IgFLN16 24, FLNs complex multiple partners in close proximity to one another, potentially enhancing signal transduction by aiding assembly of networks linking receptors with signaling proteins and the cytoskeleton [5].
Where possible, experimentally high-confidence causal relationships were used to construct the regulatory networks following the same approach adopted during the assembly of the network models used in RCR analysis.
Combining two well-developed algebraic, discrete and logical methods (Boolean network construction and FCA) it was possible to include human expert knowledge in all different phases (assembly of the network, adjustment to the data, and choice of relevant temporal rules), with the exception of the challenging data discretisation step.
River basin is a unit of natural runoff process and it can be considered as an assembly of flux network of water and various materials including sediment and nutrients.
The results show that for any higher order assembly of the network, optimal internal radius ratio is always 21/2 for wetted surface constraint, and 23/7 for total duct volume constraint.
Dynamical assembly of cytoskeletal network is believed to play an important role in driving these assembly processes.
Based on these studies, it is possible that knock down of proteins that reside at focal adhesions probably may lead to incomplete or improper assembly of the network of proteins found at the focal adhesions.
These events are largely based on actin microfilament system: protrusion is believed to be driven by assembly of actin network at the leading edge, while generation of the tension force to pull the cell body and retract the tail depends, at least in part, on the contraction of actin network by motor protein myosin II [1], [2].
This modular architecture makes assembly of the network considerably simpler than the result appears in Fig. 2. To facilitate clarification of subsequent diagrams, one of the excitatory connections is drawn in green in Fig. 4F, G. Non-hexagonal n-RANCs for the outputs labeled 2n−1−1 and 2n−1 are also modular, as described previously in the recursive process for constructing them.
The network analysis process does not require clustering or statistical analysis other than when defining the probability (p-value) of the assembly of a network of a certain size out of randomly selected relevant nodes (described in the Methods).
