The phrase "assembly is challenging" is correct and usable in written English.
It can be used to describe the difficulty or complexity involved in the process of assembling something, whether it's a product, a project, or a group of people.
Example: "The assembly is challenging, requiring careful attention to detail and a thorough understanding of the instructions."
Alternatives: "putting it together is difficult" or "the assembly process is tough."
For species with larger genomes i.e. plants, plant-infecting insects or pathogenic protists de novo assembly is challenging and often dependent on many non-intuitive parameters such as k-mer value selection.
However, de novo transcriptome assembly is challenging due to short reads, lack of reference sequences and the need for development of improved bioinformatic tools to facilitate data analysis [ 8].
Tenney, a conservative Republican member of the state Assembly, is challenging Rep.
Early steps in spliceosome assembly are challenging to study biochemically and structurally due to compositional and conformational dynamics.
Due to the ancestral WGD in the salmonid lineage, genome assembly and annotation is challenging, but some problems (e.g., gene identification) can be ameliorated with an increased knowledge of which sections of the genome are being expressed.
Furthermore, the assembly of repeated regions is challenging.
Thus, the assembly of shorter reads is challenging in terms of computational power and resources needed.
Because availability of known microbial genome references are limited and de novo assembly of metagenome sequences is challenging, the alignment-free sequence signature method is a promising approach for analyzing multiple metagenomic samples.
This variation (present as heterozygosity in a single individual) is challenging for standard assembly approaches because it is difficult to distinguish allelic sequences from truly paralogous loci that have low divergence between them.
The problem is referred to as 'haplotype assembly' (Lancia et al., 2001), which is challenging in the following two aspects: Reads are sampled from either of the two haplotypes and no information is given about which one they come from.
Because maintenance and assembly tasks can be very complex, training technicians to efficiently perform new skills is challenging.
