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Given the interdependence of anchoring junction assembly and regulation, to test whether loss of E-cadherin based adherens junctions results in the reciprocal loss of desmosomal adhesion, we generated a transgenic DU145 cell line that stably expressed a shRNAmir-E-cadherin construct and showed a 99.6% reduction in mRNA E-cadherin expression (referred as EcadKD; Fig. 2A).
Moreover, since the driving forces for peptide self-assembly including hydrogen bonding, electrostatic repulsion, and π π stacking have high interdependence with each other, changes in aromatic interaction induce a Domino effect and cause a shift of force balance to a new state.
However, the importance of this observation in the current manuscript helps to clarify a point of confusion in the field surrounding the interdependence of CENP-C and CENP-T/W/S/X and their roles in centromere assembly.
Gene regulatory networks (GRNs) guiding differentiation of cell types and cell assemblies in the nervous system are poorly understood because of inherent complexities and interdependence of signaling pathways.
It is the only institution of its kind in the world, and the only international assembly in which the representatives of various countries sit together regularly with the aim of promoting the interdependence of North and South.
The job demanded interdependence.
Reduce your interdependence.
Interface becomes interdependence….
Check for interdependence.
What about nuclear interdependence?
Interdependence defines our time.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com