Exact(11)
Below, we investigate some functional consequences of the independent coding and coordinated assembly hypotheses and show that, despite the advantage of assembly coordination in generating robust sequential activity patterns, it suffers from severe limitations in remapping and storage of multiple spatial maps.
Saving mothers' lives requires the strategic assembly, coordination and deployment of resources -- skilled doctors and midwives, ambulances, roads, clean sheets and basic medical tools, just to name a few.
This failure to detect evidence of assembly coordination gives further support to the independent coding hypothesis.
In particular, it is unclear whether this shuffling procedure could be modified to obtain a test for assembly coordination with greater statistical specificity and if so, whether it would reveal assembly coordination within experimental datasets.
While alternative forms of assembly coordination might also be considered, we choose the present model for two key reasons.
First, this model is simple, containing relatively few adjustable parameters while capturing the essential features of sequence generation via assembly coordination.
Similar(49)
Thus, inter-assembly coordination is not required to account for these findings.
Therefore, previous evidence for intra-assembly coordination can be explained by a failure to account for the phase dependence of CA1 firing.
Further experimental support for the notion of inter-assembly coordination has come from an analysis suggesting that single cell phase precession is less precise than observed theta sequences (Foster and Wilson, 2007).
DOI: http://dx.doi.org/10.7554/eLife.03542.011 For the independent coding model, we find that peer prediction provides a higher level of information about a neuron's firing than predictions based on place and nondirectional phase fields, despite the absence of intra-assembly coordination in our simulated data.
While the above analysis demonstrates that intra-assembly interactions are not required to account for membership of CA1 assemblies, several studies support a role for inter-assembly coordination in the generation of theta sequences (Dragoi and Buzsáki, 2006; Foster and Wilson, 2007; Maurer et al., 2012; Gupta et al., 2012).
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