Sentence examples for assembly checkpoints from inspiring English sources

This study provides clues to the possible functional links between the spindle and phragmoplast assembly checkpoints, ensuring failsafe mitosis.

More recently Chk1's role has expanded into regulating Tousled-like kinases for chromatin remodeling [11], centrosome- and spindle assembly checkpoints [12], [13] and the repression of transcription of the cell cycle proteins cyclin B and Cdk1 [15], [15].

In fact, they play pivotal role, ranging from DNA damage and spindle assembly checkpoints - before entering mitosis - to kinetochore and centrosome maturation and separation, in regulating the timing of entrance and exit of mitosis [40].

Among the drugs used in this study, while demecolcine prevented proteolysis of cyclin B by activating spindle assembly checkpoints, MG132, the specific inhibitor of proteasome catalytic activity, prevented cyclin B degradation directly [46], [47].

MDA-MB-468 and MDA-MB-231 cells treated with paclitaxel were induced to M-phase arrest and showed ring-like staining, which was followed by apoptosis, suggesting that both cell lines possessed functional spindle assembly checkpoints.

Indeed, recent studies demonstrate that UbcH10 promotes the dissociation of Mad2 from Cdc20, a crucial step in the metaphase to anaphase transition in which important molecules are involved in the organization of appropriate spindle assembly checkpoints [ 9, 10].

spindle assembly checkpoint.

In prometaphase the APC/C becomes active again, but is controlled by the spindle assembly checkpoint.

Here, we report that BRCA2 regulates the spindle assembly checkpoint (SAC).

ITC, isothermal titration calorimetry; KARD, kinetochore attachment and regulatory domain; PP2A, protein phosphatase 2A; SAC, spindle assembly checkpoint.

Spindle assembly checkpoint (SAC) is a surveillance mechanism safeguards the accurate separation of sister chromatids (Musacchio, 2015).