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Remarkably, defective SMN complex function in snRNP assembly causes a significant decrease in the levels of a subset of spliceosomal snRNPs and preferentially affects the accumulation of U11 snRNP of the minor splicing pathway in tissues from severe SMA mice.
Remarkably, defective SMN complex function in snRNP assembly causes a significant decrease in the levels of a subset of snRNPs and preferentially affects the accumulation of U11 snRNP a component of the minor spliceosome in tissues of severe SMA mice.
Yeast rpS5, a constituent of the SSU head domain, is one well studied example of a r-protein whose lack of assembly causes distinct SSU maturation phenotypes: in vivo depletion of rpS5 leads to nuclear entrapment and degradation of nascent SSUs and to a delay of early nuclear pre-18S rRNA processing events [14].
Failure of this bipolar centrosome assembly causes multipolar spindle structures and aberrant chromosomes segregation that prevent normal cell division [ 5].
In the tetrahedron, all cooperative assembly events are intended to occur intramolecularly, involving two initiator domains on the same molecule, and thus, each such assembly causes the formation of a ring.
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Thus, defects in peripherin assembly caused by CMT2B-causing RAB7A mutant proteins could, in turn, affect neurofilament assembly and axonal transport leading to neurodegeneration.
It eventually determined that wheel "flutter" could cause friction on a cable, which could compromise circuits that were related to the air-bag assembly, causing the air-bag warning light to illuminate.
More analysis is required to see if thermal expansion of optical components or the mounting assembly caused the vertical offset.
A single-base mutation was added to the G-quadruplex domain to prevent the nonspecific SWCNTs assembly caused by the formation of the interparticle G-quadruplex.
The DNA assembly caused the departure of Fc from the electrode and the approach of MB to the electrode, which led to the signal decrease and increase of Fc and MB respectively for ratiometric readout.
Mutations in lamin genes leading to defects in filament assembly cause a group of rare genetic disorders known as laminopathies.
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