One uses engineering concepts to design and build artificial gene networks from component parts that exist in nature, but once assembled function in unnatural ways[2], [3], [4], [5].
The data suggest that a precisely assembled macrocomplex functions to reliably convert TCR-pMHCII confinement into reproducible signals that orchestrate adaptive immunity.
Two kinds of centrality can be distinguished: (1) a natural centrality that is mainly based on the location of a site in relation to its local hinterland as well as supra-regional landscape characteristics and (2) a politically controlled centrality that is caused by human efforts to assemble central functions.
The plasmid carries the four gene clusters cox (14.54 kb, 12 genes), cbb (13.33 kb, 13 genes), hox (23.35 kb, 19 genes plus one ORF) and tra/trb (25.01 kb, 22 genes plus 2 ORFs), which assemble the functions required for the utilization of CO, CO2 or H2, and the conjugal transfer of the plasmid, respectively.
We propose a new dynamic model of how the destruction complex regulates Wnt signaling and how this goes wrong in cancer, providing insights into how this multiprotein signaling complex is assembled and functions via multivalent interactions.
We also removed the overly broad claim about a paradigm from the Abstract – it now reads: "We propose a new dynamic model of how the destruction complex regulates Wnt signaling and how this goes wrong in cancer, providing insights into how this multiprotein signaling complex is assembled and functions via multivalent interactions".
Biopolymers Interaction Assemble, Function and Interaction of Proteins Laboratory.
Genetic recombination maps provide important frameworks for comparative genomics, identifying gene functions, assembling genome sequences and for breeding.
Speaking in Australia, the US secretary of state, John Kerry, promised "additional political, economic and security options" once the new prime minister assembled a functioning government.
U.S. State Department officials have been busy for months in behind-the-scenes efforts trying to assemble a functioning pro-Western Syrian opposition with a head and tail that speaks together.
A variety of microscopic techniques, as well as NMR structure determination of fragments of the protein, have now provided clearer and correlated views of how these structures are assembled and function as intercellular conduits.
