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This notion is in line with work from our laboratory, showing that higher-order IRE1 assemblies are required for full activation of IRE1's ribonuclease activity in yeast and mammals [ 8, 29, 30].
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The fact that spliceosome components from distinct subcomplexes that act at different steps of spliceosome assembly are required for cohesion suggests that compromised pre-mRNA splicing in general could be responsible for the loss of sister chromatid cohesion.
Assembly is required.
And no assembly is required.
Then, as they say, some assembly is required.
But as always with Mahler, some assembly was required.
Some assembly is required (not much, actually), and it costs $770.
If assembly is required, you may reconsider because it will require significantly more time.
Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes.
Moreover, EMC assembly is required for silencing a specific subset of the entire Mmi1 regulon.
Students who elected not to attend the assembly were required to report to study hall.
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