We propose a new dynamic model of how the destruction complex regulates Wnt signaling and how this goes wrong in cancer, providing insights into how this multiprotein signaling complex is assembled and functions via multivalent interactions.
We also removed the overly broad claim about a paradigm from the Abstract – it now reads: "We propose a new dynamic model of how the destruction complex regulates Wnt signaling and how this goes wrong in cancer, providing insights into how this multiprotein signaling complex is assembled and functions via multivalent interactions".
Taken together, our data provide molecular insights into how lateral diffusion barrier might assemble and function in eukaryotic membranes.
Ruban and coworkers [ 19] argued that in the absence of one of the PSII supercomplex main components, another antenna protein may be recruited to replace a mutated or absent protein, therefore allowing the main complex to assemble and function correctly.
CRLs are therefore involved in a myriad of cellular processes, including cell-cycle control, gene transcription, and signal transduction, so it is of great interest to study how these complex molecular machines assemble and function.
Together, these data indicate that the Unc-labelled structure at the distal centriole, the transition zone or perhaps a proximal substructure of the transition zone, fails to assemble and to function normally upon Taxol treatment, leading to membrane docking failure.
The energetic properties of cooperatives are useful for understanding of how the essential macromolecular machines of cellular function are assembled and how they work [37].
Corresponding studies of a pore-only construct (consisting of the S5 and S6 helices linked by the interconnecting P-loop and the CTD) of the NaChBac homologue NaVSP (39% identical) have indicated that the pore subdomains can also assemble, fold, and function in a manner independent of the voltage sensor.
Scientists are trying to understand how microfibrils assemble and function, so they can understand how this damage occurs.
Despite this, our fundamental knowledge of the structure of membrane proteins and how they fold, assemble, and function remains limited.
